We hope 15:20, 29 July 2006 (UTC) Notes re: resistance to protamine. Lucky had immune-mediated insulin resistance to both human and beef insulins. Giving him insulins of these two species were like giving no insulin at all because his body destroyed it, believing it to be a harmful invader. They both were Lente-types.
He regulated easily on pork lente--Iletin II Lente--Lilly's old U100 pork lente. At discontinuance of the insulin, we had to switch to their U100-protamine-suspended pork insulin, Iletin II NPH. The only difference between the two insulins was type-one was lente (zinc suspension), the other NPH/isophane (containing protamine). It took almost twice as much NPH/isophane insulin to have the same effect on his blood glucose levels when compared to pork lente. Not resistant at all to the insulin itself, but to the suspension method which extended it.
Because of his problems with neuropathy, dry skin & coat/poor hair coat, irritated eyes and extreme lethargy which never occurred until being given an NPH/isophane insulin, we made application to receive Caninsulin/Vetsulin before its US approval. He was on pork NPH/isophane insulin for about 2 months until we could obtain Caninsulin/Vetsulin. All complications reversed within 2 weeks of beginning Caninsulin/Vetsulin treatment--to the point where he shed his sparse, dry winter coat from pork NPH. It was replaced with the usual shiny, healthy one from pre-diabetes and post-diabetes pork lente days.