ReliOn/Novolin NPH
NPH/Isophane by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novolin
Also known as Novolin N, Insulatard, Protaphane
Similar to  
Action in cats  
  • onset 1-2h,
  • sharp peak 4-10h
  • duration 8-12h[1][2]
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h[3],
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 18 months
When opened 28 days room temp.
In pen 28 days room temp.

An NPH/isophane crystal insulin[4][5].

Technical detailsEdit

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

These times seem to be similar in dogs, but considerably compressed in cats, possibly because of cats' faster metabolism.

Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on

It is a protamine suspension insulin, made by Novo Nordisk especially for Wal-Mart and Sam's Club[6].

The only difference between the vials is the addition of the ReliOn name and the cheaper price. There is no quality difference between this insulin and Novolin N, Insulatard or Protaphane[7].

Other comparable insulins by other manufacturers are: Humulin N[8][9], Humulin I[10]--the "I" an abbreviation for isophane[11][12], Insuman Basal[13][14].

Further ReadingEdit



  1. Insulins-North American Veterinary Conference-2005
  2. Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs & Cats-Nelson-OSU Endocrinology Symposium 2006-Page 41
  3. Insulins-North American Veterinary Conference-2005
  4. EMEA Scientific Discussion-Insulatard
  5. Prescribing Novo Insulins
  6. Photo of ReliOn/Novolin insulins. ReliOn/Novolin N is in center.
  7. EMEA Scientific Discussion-Protaphane
  8. US FDA-Humulin N
  9. Humulin N NPH/Isophane Insulin
  10. Humulin I Prescribing Information
  11. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin I
  12. Lilly EU/UK Product Sheet & Time Activity Profiles
  13. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Basal
  14. Insuman Prescribing Information
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