Penmix 50[1]
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Actraphane 50/50, Mixtard 50[2]
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type soluble
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate cartridges/pens in use

Penmix 50 is Novo Nordisk's r-DNA/GE/GM human insulin mix[3]consisting of 50% R/neutral insulin and 50% NPH/isophane insulin[4]. It consists of 50% isophane insulin crystals[5].

It is the same as Humulin 50/50[6], Actraphane 50/50[7] Mixtard 50[8], and Insuman Comb 50[9][10].

Eli Lilly produced a similar insulin in the EU & UK called Humulin M5[11]; it was discontinued in July 2004[12]

Mixtard 50 was discontinued December 31, 2007[13][14].


  1. Medsafe NZ Penmix 50
  2. Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 50
  3. Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 50
  4. Prescribing Novo Insulins
  5. EMEA Scientific Discussion-Mixtard
  6. Humulin 50/50-NPH;R Human Insulin
  7. EMEA Scientific Discussion Actraphane
  8. Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 50
  9. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Comb 50
  10. Prescribing Insuman Insulins
  11. Lilly EU/UK Product Sheet & time Activity Profiles
  12. Withdrawal of Humulin M5-July 2004
  13. Insulin Discontinuations-UK
  14. Chart of Discontinued Novo Human Insulins
Community content is available under CC-BY-SA unless otherwise noted.