Penmix 50

Use and Handling
Penmix 50^[1]
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting	r-DNA/GE/GM
U100	isophane
Line	Novo
Also known as	Actraphane 50/50, Mixtard 50^[2]
Similar to	Humulin 50/50, Insuman Comb 50 Humulin M5
Action in cats	onset Xh, peak Xh duration Xh
Action in dogs	onset 0.5-3h, peak 2-10h, duration 4-24h
Type	soluble
Shelf Life	30 months
When opened	6 weeks room temp.
In pen	6 weeks room temp.
Notes	protect from light and heat Do Not Freeze Do not use if product does not re-suspend Roll Do not use intravenously Do not refrigerate cartridges/pens in use

Penmix 50 is Novo Nordisk's r-DNA/GE/GM human insulin mix^[3]consisting of 50% R/neutral insulin and 50% NPH/isophane insulin^[4]. It consists of 50% isophane insulin crystals^[5].

It is the same as Humulin 50/50^[6], Actraphane 50/50^[7] Mixtard 50^[8], and Insuman Comb 50^[9]^[10].

Eli Lilly produced a similar insulin in the EU & UK called Humulin M5^[11]; it was discontinued in July 2004^[12]

Mixtard 50 was discontinued December 31, 2007^[13]^[14].

References[]

[1] Medsafe NZ Penmix 50

[2] Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 50

[3] Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 50

[4] Prescribing Novo Insulins

[5] EMEA Scientific Discussion-Mixtard

[6] Humulin 50/50-NPH;R Human Insulin Remedyfind.com

[7] EMEA Scientific Discussion Actraphane

[8] Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 50

[9] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Comb 50

[10] Prescribing Insuman Insulins

[11] Lilly EU/UK Product Sheet & time Activity Profiles

[12] Withdrawal of Humulin M5-July 2004

[13] Insulin Discontinuations-UK

[14] Chart of Discontinued Novo Human Insulins

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