Penmix 40[1]
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Mixtard 40[2]
Similar to None
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate in use cartridges/pens.

An intermediate-acting, mixed insulin[3][4] of 40% R/neutral insulin and 60% NPH/isophane insulin[5] made by Novo Nordisk. Mixtard 40[6] contains 60% isophane insulin crystals.

This insulin is similar to Novo's Mixtard 40, which was was discontinued December 31, 2007.[7][8]


  1. Medsafe NZ Penmix 40
  2. Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 40
  3. Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 40
  4. Prescribing Novo Insulins
  5. Humulin 40/60-NPH;R Human Insulin
  6. EMEA Scientific Discussion-Mixtard
  7. Insulin Discontinuations-UK
  8. Chart of Discontinued Novo Human Insulins