Penmix 30[1]
R/Neutral/NPH/Isophane Mix by Novo Nordisk
short-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Actraphane 30/70, Novolin 70/30, Mixtard 30[2], ReliOn/Novolin 70/30
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate in use cartridges/pens.

Penmix 30 is Novo Nordisk's r-DNA/GE/GM human insulin mix[3][4] consisting of 30% R/neutral insulin and 70% NPH/isophane insulin crystals[5].

It is the same as Humulin 70/30[6].

Novo calls the same mix Novolin 70/30 or ReliOn/Novolin 70/30 in North America, and Mixtard 30 or Actraphane 30/70 in the UK and EU.

A comparable insulin made by Eli Lilly is Humulin M3[7][8][9]; another by Novo is Actraphane 30/70[10] .


  1. Medsafe NZ Penmix 30
  2. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Mixtard 30
  3. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Mixtard 30
  4. Prescribing Novo Insulins
  5. EMEA Scientific Discussion-Mixtard
  6. Humulin 70/30-NPH;R Human Insulin
  7. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin M3
  8. Humulin M3 Prescribing Information
  9. Lilly EU/UK Product Sheet & Time Activity Profiles
  10. EMEA Scientific Discussion Actraphane
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