|PZI by IDEXX|
|long-acting||Bovine 90% Porcine 10%|
|Also known as||formerly Blue Ridge PZI, IDEXX PZI|
|Similar to||other PZI formulations|
|Action in cats|
|Action in dogs|
|Use and Handling|
|Shelf Life||36 months|
|When opened||XX days|
Some compounding pharmacies may refer to their PZI insulins as PZI Vet, but you aren't using PZI Vet unless it was made by IDEXX Labs.
PZI Vet was a 90% beef, 10% pork insulin.PZI Vet was absolutely identical to the old Eli Lilly Iletin I beef/pork PZI insulin,in everything but the strength. Blue Ridge purchased the patent rights for it from Lilly. Its duration was similar to that of BCP PZI.
Before IDEXX purchased Blue Ridge Pharmaceuticals and re-named the insulin as PZI Vet, this study showing efficacy was done.
PZI Vet came in U40 strength only. You used U40 syringes or used U100 syringes and the conversion table at the link below.
The IDEXX Internet site says PZI Vet was good for three years after date of manufacture. You may have found that you used your vial in much less than three years.
Usage and handling
PZI Vet package insert.
It is not advised to dilute or combine PZI Vet with other insulins.
Refrigerate PZI Vet when not in use. It should not lose effectiveness if accidentally left out as long as not in direct sunlight or heat. However, watch for signs of decreased effectiveness (higher blood glucose levels) just in case.
No Combining For PZI
Obtaining PZI Vet
PZI Vet is unfortunately being discontinued.
April 8, 2008 Dear Concerned Cat Owner, Recently there have been some developments regarding the availability of PZI VET® (protamine zinc insulin), and I wanted to update you on the situation because it may impact your diabetic cat. You may know that PZI VET is derived from bovine and porcine pancreatic glands, and unfortunately, the supply of our original raw material has been exhausted. As there are no FDA approved facilities for harvesting bovine pancreatic tissue, we have determined after extensive study that further production of animal source insulins is not practical in a modern manufacturing environment. Therefore, following the sale of our existing inventory, IDEXX will no longer manufacture or sell any animal-based insulin. We are currently in the process of notifying veterinarians who prescribe PZI-VET of the situation. As of April 1, 2008, there was a considerable inventory in distribution, so please consult with your own veterinarian on the best course of action for your cat. We appreciate that feline diabetes is a chronic condition requiring ongoing treatment and monitoring. Accordingly, IDEXX remains committed to the treatment of this disease. We are working diligently to develop and bring to market a new insulin product for the treatment of diabetes in cats. Sincerely, Cynthia Cole DVM, PhD, DACVCP Manager, Professional Services Group IDEXX Pharmaceuticals, Inc.
Boehringer Ingelheim purchased PZIVet from IDEXX November 11, 2008.
Quoting from BI's website:
"As of November 20, 2008 Boehringer Ingelheim Vetmedica, Inc., (BIVI) has assumed the responsibility of providing technical support for PZI VET® (Protamine Zinc Insulin) from Idexx Pharmaceuticals, Inc."
"A considerable supply of PZI VET is currently available. Please check with your BIVI authorized distributor to make a purchase. If your preferred distributor is out of stock, please contact 866-638-2226 for a list of available distributors."
In past here's how it worked: You get PZI Vet from your vet, or with a prescription from your vet, you can order from an online pet pharmacy such as Drfostersmith.com. See also the felinediabetes.com list of PZI sources at the link below.
If you are in Canada, your vet may be able to obtain PZI Vet for you through Health Canada's Emergency Drug Release program. With it, you are able to receive up to 6 months worth of insulin; a C$ 50.00 fee for the application is required . If permitted, you would then be eligible to import PZI insulins such as PZI Vet.
The program is similar to Health Canada's Special Access Programme  for importing necessary drugs for people.
Some vets marked up the cost of PZI Vet to make a large profit. A reasonable price was around $90 US.
- Wiki cases-Feline PZI Vet users
- Regulating the Diabetic Cat Using PZI Vet Insulin-Page 3
- Comparison of 2 Ultralente Insulin Preparations With Protamine Zinc Insulin in Normal Cats-American Journal of Veterinary Research-1994
- Animal Help Pharmaceutical Index
- Petsulin Protamine Zinc Page 5 feline duration
- Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs & Cats-Nelson-OSU Endocrinology Symposium 2006-Page 41
- Insulins-North American Veterinary Conference
- Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs 7 Cats-Page 40
- IDEXX Laboratories Website-PZI Vet
- BD Diabetes-Insulins for Cats-PZI Vet
- Complications of Insulin Therapy in Diabetic Cats-Dr. Richard Nelson (Page 3)
- JAVMA-2001-Efficacy of Protamine Zinc Insulin for Treatment of Diabetes Mellitus in Cats
- Conversion Table-Using U100 Syringes With U40 Insulin-Felinediabetes.com
- PZI Vet Package Insert
- Excess Protamine in Protamine Zinc Insulin Formula
- Comparison of Injection Techniques for Soluble and Protamine Zinc Insulins in Diabetes Mellitus PubMed-Practitioner-1975
- NHS UK-Protamine Zinc Insulin (PZI) Binds to Soluble Insulin in Same Syringe
- Petsulin Protamine Zinc Page 5-Incompatibilities
- DVM 360-IDEXX sells PZI Vet to BI
- Boehringer Ingleheim Website Re: PZIVet
- Doctors Foster & Smith Website
- PZI Sources-Felinediabetes.com
- Health Canada-Veterinary: Emergency Drug Release Information
- Health Canada-Emergency Drug Release Form
- Health Canada-Special Access Programme