Novolin N
NPH, Isophane by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 Isophane
Line Novolin
Also known as Insulatard, ReliOn/Novolin NPH, Protaphane
Similar to  
Action in cats  
  • onset 1-2h,
  • sharp peak 4-6h,
  • duration 8-12h[1][2]
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h[3],
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 18 months
When opened 28 days room temp.
In pen 28 days room temp.

Novo Nordisk's intermediate-acting human insulin, known in some countries as Insulatard[4] or Protaphane[5].

Technical detailsEdit

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

These times seem to be similar in dogs, but considerably compressed in cats, possibly because of cats' faster metabolism.

Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on

Like Humulin N[6][7], it is an isophane crystal protamine suspension insulin[8].

Other brands are: Humulin I[9][10][11] by Eli Lilly and Insuman Basal[12][13] byAventis.

Further ReadingEdit


How to use NPH insulins on cats by Kimber & Bunny and the FDMB


  1. Insulins-North American Veterinary Conference-2005
  2. Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs & Cats-Nelson-OSU Endocrinology Symposium 2006-Page 41
  3. Insulins-North American Veterinary Conference-2005
  4. Prescribing Novo Insulins
  5. EMEA Scientific Discussion-Protaphane
  6. US FDA-Humulin N
  7. Humulin N NPH/Isophane Insulin
  8. EMEA Scientific Discussion-Insulatard
  9. Humulin I Prescribing Information
  10. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin I
  11. Lilly EU/UK Product Sheet & Time Activity Profiles
  12. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Basal
  13. Insuman Prescribing Information
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