Diabetes in Pets
Novolin N
NPH, Isophane by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 Isophane
Line Novolin
Also known as Insulatard, ReliOn/Novolin NPH, Protaphane
Similar to  
Action in cats  
  • onset 1-2h,
  • sharp peak 4-6h,
  • duration 8-12h[1][2]
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h[3],
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 18 months
When opened 28 days room temp.
In pen 28 days room temp.

Novo Nordisk's intermediate-acting human insulin, known in some countries as Insulatard[4] or Protaphane[5].

Technical details

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

These times seem to be similar in dogs, but considerably compressed in cats, possibly because of cats' faster metabolism.

Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on Felinediabetes.com

Like Humulin N[6][7], it is an isophane crystal protamine suspension insulin[8].

Other brands are: Humulin I[9][10][11] by Eli Lilly and Insuman Basal[12][13] byAventis.

Further Reading


How to use NPH insulins on cats by Kimber & Bunny and the FDMB