Monotard Pork | |
Lente by Novo Nordisk | |
intermediate-acting | Porcine |
U100 | Zinc |
Line | Novo |
Also known as | N/A |
Similar to | :
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Action in cats |
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Action in dogs |
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Use and Handling | |
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Type | cloudy |
Shelf Life | 24 months |
When opened | 28 days |
In pen | N/A |
Notes |
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Monotard Pork was a U100, 100% porcine insulin made by Novo Nordisk. It was an intermediate-acting, lente-type. Eli Lilly also made a comparable pork lente insulin, Iletin II Lente[1]. As the other Lente insulins[2], it was a suspension of crystalline (ultralente) and amorphous (semilente) insulin in a ratio of 7 crystalline parts to 3 amorphous parts.
Monotard Pork was also identical to Caninsulin[3][4]/Vetsulin with the only exception being its strength: Pork Monotard was U100 strength, while Caninsulin/Vetsulin is U40.
No Lente-type insulin regardless of species can contain any NPH/isophane insulin[5] or any R/Neutral insulin[6]. Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral. The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect[7].
References
- ↑ Drugs.com-Copy of Iletin II Lente Patient Information Leaflet
- ↑ EMEA Scientific Discussion-Monotard
- ↑ Horn Mitten Study-Refers to the Church Study Equating Caninsulin with Novo's old Pork Monotard
- ↑ Australian Veterinary Journal-More Re: Caninsulin Being Equivalent to Pork Monotard
- ↑ Combining Lente-type Insulins with Phenol-Preserved Insulins
- ↑ Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect
- ↑ Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente Diabetes Care-1980
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins