| Monotard Pork | |
| Lente by Novo Nordisk | |
| intermediate-acting | Porcine |
| U100 | Zinc |
| Line | Novo |
| Also known as | N/A |
| Similar to | :
|
| Action in cats |
|
| Action in dogs |
|
| Use and Handling | |
|---|---|
| Type | cloudy |
| Shelf Life | 24 months |
| When opened | 28 days |
| In pen | N/A |
| Notes |
|
Monotard Pork was a U100, 100% porcine insulin made by Novo Nordisk. It was an intermediate-acting, lente-type.
Eli Lilly also made a comparable pork lente insulin, Iletin II Lente[1][2].
As the other Lente insulins[3], it was a suspension of crystalline (ultralente) and amorphous (semilente) insulin in a ratio of 7 crystalline parts to 3 amorphous parts.
Monotard Pork was also identical to Caninsulin[4][5]/Vetsulin with the only exception being its strength: Pork Monotard was U100 strength, while Caninsulin/Vetsulin is U40.
What Lente Is Not[]
No Lente-type insulin regardless of species can contain any NPH/isophane insulin[6] or any R/Neutral insulin[7].
Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral[8].
The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect[9][10][11].
Combining Lente Family Insulins[]
Insulin manufacturers[12] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins[13][14][15][16].
|
None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with[17] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action[18]. Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins[19]. | ||
References[]
- ↑ Drugs.com-Copy of Iletin II Lente Patient Information Leaflet
- ↑ US-FDA Iletin II Lente Discontinuation Material 2003
- ↑ EMEA Scientific Discussion-Monotard
- ↑ Horn Mitten Study-Refers to the Church Study Equating Caninsulin with Novo's old Pork Monotard
- ↑ Australian Veterinary Journal-More Re: Caninsulin Being Equivalent to Pork Monotard
- ↑ Combining Lente-type Insulins with Phenol-Preserved Insulins
- ↑ Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect
- ↑ Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination
- ↑ Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente Diabetes Care-1980
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins - ↑ Solubility Changes on Mixing Short- and Long-acting Insulin Preparations-South African Medical Journal-1988
- ↑ Resource Guide 2005-American Diabetes Association
- ↑ Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins
- ↑ Availability of Soluble (R/Neutral) Insulin in Mixed Preparations of Crystalline (Lente) & Ultralente GE Insulins-Clinical Therapeutics-1991
- ↑ Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin-Diabetes Care-1987
- ↑ Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes Research & Clinical Practice-1983
- ↑ RxEd.org-Insulin Therapy-Mixing Precautions
- ↑ Phenol Preservatives & Lente-type Insulins--A Bad Combination
- ↑ RxEd.org-Insulin Therapy-Mixing Precautions
- ↑ RxEd.org-Insulin Therapy-Mixing Precautions