Mixtard 50

Mixtard 50
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Actraphane 50/50, Penmix 50[1]
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type soluble
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate cartridges/pens in use

Mixtard 50 is Novo Nordisk's r-DNA/GE/GM human insulin mix[2]consisting of 50% R/neutral insulin and 50% NPH/isophane insulin[3]. It consists of 50% isophane insulin crystals[4].

It is the same as Humulin 50/50[5], Actraphane 50/50[6] and Insuman Comb 50[7][8].

Eli Lilly produced a similar insulin in the EU & UK called Humulin M5[9]; it was discontinued in July 2004[10]

Mixtard 50 was discontinued December 31, 2007[11][12].


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