Mixtard 40
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Penmix 40[1]
Similar to None
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate in use cartridges/pens.

An intermediate-acting, mixed insulin[2][3] of 40% R/neutral insulin and 60% NPH/isophane insulin[4] made by Novo Nordisk. Mixtard 40[5] contains 60% isophane insulin crystals.

Mixtard 40 was discontinued December 31, 2007.[6][7]


  1. Medsafe NZ Penmix 40
  2. Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 40
  3. Prescribing Novo Insulins
  4. Humulin 40/60-NPH;R Human Insulin
  5. EMEA Scientific Discussion-Mixtard
  6. Insulin Discontinuations-UK
  7. Chart of Discontinued Novo Human Insulins
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