Diabetes in Pets
Insuvet Neutral
R,Neutral by Pfizer Animal Health
short-acting Bovine
U100 none
Line Insuvet
Also known as beef R, beef neutral
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h
Use and Handling
Type soluble
Shelf Life 24 months
When opened 28 days room temp.
In pen 28 days room temp.
  • protect from light and heat
  • Do Not Freeze
  • May be used intravenously

This is Pfizer Animal Health's U100 100% bovine R/neutral insulin[1] in the Insuvet product line[2].

Technical details

NOAH[3] is the UK's veterinary medicines compendium. Their entry for Insuvet neutral describes it as U100 highly purified bovine neutral  insulin injection BP (British Pharmacopia)presented in 10ml vials. Shelf life[4] of Insuvet Neutral is 3 years.

Usage and handling

It is described as having a rapid onset[5] and short activity duration. [6][7] Like all other R/neutral insulins, it has had nothing added to change its speed or length of activity. Since it is soluble, it is able to be administered intravenously, intramuscularly or subcutaneously.

Store the insulin at[8] the insulin at 2C-8C. Do not freeze. Insulin should only be in use 28 days before replacement.

Dosage information[9] for using Insuvet Neutral in ketoacidosis.

Comparable to CP Pharma's Hypurin Vet Neutral (veterinary use only) and Hypurin Bovine Neutral (approved for humans). It is available only in the UK. The insulin is also comparable to the former Lilly insulin, Iletin I R[10]

Feline insulin compared with Bovine, Human, & Porcine versions. Up to 4 amino acids differ. The closest match is bovine with only one amino acid difference; the lease close is human with four amino acid differences.

Best Pet Pharmacy stocks this for sale in the UK.