Insuvet Lente | |
Lente by Pfizer Animal Health | |
intermediate-acting | Bovine |
U100 | Zinc |
Line | Insuvet |
Also known as | beef lente |
Similar to | |
Action in cats |
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Action in dogs |
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Use and Handling | |
---|---|
Type | cloudy |
Shelf Life | 36 months |
When opened | 28 days |
In pen | N/A |
Notes |
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Pfizer Animal Health UK produces bovine insulins for veterinary use under the brand name Insuvet. This is their U100, intermediate-acting lente[2] insulin[3][4][5].
What Lente Is Not[]
No Lente-type insulin regardless of species can contain any NPH/isophane insulin[6] or any R/Neutral insulin[7][8].
Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral[9].
The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect[10].
Technical details[]
The official NOAH (National Office of Animal Health)[11] description of Insuvet Lente is that it is a highly purified bovine Zinc suspension insulin as per British Pharmacopeia (BP). The "mixed" tag refers to the 30% semilente, 70% ultralente composition of all lente insulins. It is U100 and presented in 10ml vials. The insulin[12] has a shelf life of 3 years.
Usage and handling[]
Insuvet Lente[13]is classed as being a medium to long duration insulin given subcutaneously. Onset is 1-3 hours after injection, with a peak at 6-12 hours and a total duration of 18-28 hours.
Dosage information for Insuvet Lente[14] can be found here. To be given subcutaneously[15]only. Store at 2-8 C[16] at 2-8 C. Insuvet Lente requires rolling and should not be used if product does not re-suspend. Do not freeze. Vials are to be used within 28 days of their first use.
Comparable to CP Pharma's Hypurin Bovine Lente[17], but is only approved for veterinary use. It is also comparable to Lilly's discontinued Iletin I Lente.
Combining Lente Family Insulins[]
None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with[18] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action[19]. Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins[20]. |
Insulin manufacturers[21] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins[22][23][24][25].
Best Pet Pharmacy stocks this for sale in the UK.
References[]
- ↑ Petsulin Lente Page 9 Note re:shorter feline duration
- ↑ Photo-Insuvet Lente vial and carton
- ↑ Hypurin Bovine Lente Patient Information
- ↑ Electronic Medicines Compendium (EMC) UK-Hypurin Bovine Lente
- ↑ Prescribing Bovine Insulin
- ↑ Combining Lente-type Insulins with Phenol-Preserved Insulins
- ↑ Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect
- ↑ Resource Guide 2005-American Diabetes Association
- ↑ Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination
- ↑ Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente Diabetes Care-1980
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins - ↑ NOAH Compendium UK-Insuvet
- ↑ Medications
- ↑ NOAH Compendium-UK-Insuvet-Uses
- ↑ NOAH Compendium-UK-Insuvet-Dosage & Administration
- ↑ NOAH Compendium-UK-Insuvet-Contraindications/Warnings
- ↑ NOAH Compendium-UK-Insuvet-Pharmaceutical information
- ↑ Hypurin Bovine Lente-Lente Beef Insulin Remedyfind.com
- ↑ Phenol Preservatives & Lente-type Insulins--A Bad Combination
- ↑ RxEd.org-Insulin Therapy-Mixing Precautions
- ↑ RxEd.org-Insulin Therapy-Mixing Precautions
- ↑ Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins
- ↑ Availability of Soluble (R/Neutral) Insulin in Mixed Preparations of Crystalline (Lente) & Ultralente GE Insulins-Clinical Therapeutics-1991
- ↑ Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin-Diabetes Care-1987
- ↑ Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes Research & Clinical Practice-1983
- ↑ RxEd.org-Insulin Therapy-Mixing Precautions