Insuvet Lente

Insuvet Lente
Lente by Pfizer Animal Health
intermediate-acting	Bovine
U100	Zinc
Line	Insuvet
Also known as	beef lente
Similar to	Iletin I Lente, Hypurin Bovine Lente
Action in cats	onset 1-3h, peak 4-6h duration 8-10h
Action in dogs	onset 1-3 h, peak 6-12h, duration 18-28h
Use and Handling
Type	cloudy
Shelf Life	36 months
When opened	28 days
In pen	N/A
Notes	protect from light and heat store at 2-8C Do Not Freeze Do not use if product does not re-suspend Roll Do not use intravenously

Pfizer Animal Health UK produces bovine insulins for veterinary use under the brand name Insuvet. This is their U100, intermediate-acting lente insulin.

What Lente Is Not

No Lente-type insulin regardless of species can contain any NPH/isophane insulin or any R/Neutral insulin.

Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral.

The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect.

Technical details

The official NOAH (National Office of Animal Health) description of Insuvet Lente is that it is a highly purified bovine Zinc suspension insulin as per British Pharmacopeia (BP). The "mixed" tag refers to the 30% semilente, 70% ultralente composition of all lente insulins. It is U100 and presented in 10ml vials. The insulin has a shelf life of 3 years.

Usage and handling

Insuvet Lenteis classed as being a medium to long duration insulin given subcutaneously. Onset is 1-3 hours after injection, with a peak at 6-12 hours and a total duration of 18-28 hours.

Feline insulin compared with Bovine, Human, & Porcine versions. Up to 4 amino acids differ. The closest match is bovine with only one amino acid difference; the lease close is human with four amino acid differences.

Dosage information for Insuvet Lente can be found here. To be given subcutaneouslyonly. Store at 2-8 C at 2-8 C. Insuvet Lente requires rolling and should not be used if product does not re-suspend. Do not freeze. Vials are to be used within 28 days of their first use.

Comparable to CP Pharma's Hypurin Bovine Lente, but is only approved for veterinary use. It is also comparable to Lilly's discontinued Iletin I Lente.

Combining Lente Family Insulins

None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action. Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins.

Insulin manufacturers indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins.

Best Pet Pharmacy stocks this for sale in the UK.