Diabetes in Pets
Insuman Comb 50
R/Neutral/NPH/Isophane Mix by Aventis
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Insuman
Also known as None
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 24 months
When opened 4 weeksroom temp.
In pen 4 weeks room temp.
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate in use pens/cartridges.

This is an Aventis mixed, intermediate-acting insulin[2] comprised of 50% R/neutral and 50% NPH/isophane crystal insulin[3], one of its Insuman line of products[4].

Eli Lilly produces a comparable insulin: Humulin 50/50[5]; they also formerly produced this insulin in the EU & UK under the brand name Humulin M5[6]. M5 was discontinued in July 2004[7].

Novo Nordisk produces two: Actraphane 50/50[8] and Mixtard 50[9].