Iletin II R

Use and Handling
Iletin R
R,Neutral by Eli Lilly
short-acting	Porcine
U100	none
Line	Iletin
Also known as	pork R, pork neutral
Similar to	Pork Actrapid, Hypurin Porcine Neutral
Action in cats	onset Xh, peak Xh duration Xh
Action in dogs	onset 30-60 minutes, peak 2-4h, duration 6-8h
Type	soluble
Shelf Life	24 months
When opened	28 days room temp.
In pen	N/A
Notes	protect from light and heat May be used intravenously Do Not Freeze See Pork Actrapid or Hypurin Porcine Neutral for current handling information for pork R/neutral.

North American brand name for Eli Lilly's now discontinued^[1]^[2]^[3] 100% U100 porcine R/neutral, soluble insulin^[4].

Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed^[5].

Novo Nordisk produced a similar Pork Actrapid^[6]^[7] but discontinued it at the end of December 2007^[8].

CP Pharma does also--Hypurin Porcine Neutral^[9]^[10]^[11]^[12].

Those who have expired vials of Lilly's Iletin II R appear to be able to use them safely 12 months beyond the vial's expiration date^[13]^[14].

Directly from the HealthCanada page:

"Q8: I will have unused vials of Eli Lilly's Iletin II Regular and Iletin II NPH insulin as of April 1, 2006. Can I use them past the expiry date?

A8: Health Canada understands that there may be individuals who plan on using Iletin insulins past the labelled expiry date. While Health Canada does not recommend the use of any product past the labelled expiry date, Health Canada has reviewed stability data from Eli Lilly Canada. That data indicates that if the Iletin insulins have been stored properly, the products could be used safely up to 12 months beyond the labelled expiry date."

Canineinsulin8 — Canine insulin compared with Bovine, Human, & Porcine versions. Up to 2 amino acids differ. Canine and porcine are identical^[15].

References[]

[1] US-FDA Lilly Discontinues Iletin II R & Iletin II N July 2005

[2] Iletin II R carton photo

[3] Lilly US Iletin II R Discontinuation Sheet

[4] Iletin II, etc. Regular Pork Insulin Remedyfind.com

[5] FDA-Humulin R

[6] Pork Actrapid Patient Information

[7] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Pork Actrapid

[8] Pork Actrapid Discontinuation Notice

[9] Electronic medicines Compendium (EMC) UK-Hypurin Porcine Neutral

[10] Prescribing Porcine Insulin

[11] Hypurin Porcine Neutral Patient Information

[12] Prescribing Novo Animal Insulin

[13] HealthCanada-Questions & Answers Animal Sourced Insulin

[14] Childrenwithdiabetes.com-Ask the D Team-2005

[15] Intervet-Caninsulin-Product Information

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

Iletin II R

Further Reading[]

References[]