Iletin R
R,Neutral by Eli Lilly
short-acting Porcine
U100 none
Line Iletin
Also known as pork R, pork neutral
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 30-60 minutes,
  • peak 2-4h,
  • duration 6-8h
Use and Handling
Type soluble
Shelf Life 24 months
When opened 28 days room temp.
In pen N/A

North American brand name for Eli Lilly's now discontinued[1][2][3] 100% U100 porcine R/neutral, soluble insulin[4].

Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed[5].

Novo Nordisk produced a similar Pork Actrapid[6][7] but discontinued it at the end of December 2007[8].

CP Pharma does also--Hypurin Porcine Neutral[9][10][11][12].

Those who have expired vials of Lilly's Iletin II R appear to be able to use them safely 12 months beyond the vial's expiration date[13][14].

Directly from the HealthCanada page:

"Q8: I will have unused vials of Eli Lilly's Iletin II Regular and Iletin II NPH insulin as of April 1, 2006. Can I use them past the expiry date?

A8: Health Canada understands that there may be individuals who plan on using Iletin insulins past the labelled expiry date. While Health Canada does not recommend the use of any product past the labelled expiry date, Health Canada has reviewed stability data from Eli Lilly Canada. That data indicates that if the Iletin insulins have been stored properly, the products could be used safely up to 12 months beyond the labelled expiry date."


Canine insulin compared with Bovine, Human, & Porcine versions. Up to 2 amino acids differ. Canine and porcine are identical[15].

Further ReadingEdit


Pharmacology of a U40 Porcine Lente Insulin Preparation in Diabetic Cats-Journal of Feline Medicine & Surgery-Rand & Martin-2001
Study finds Pork Actrapid--Pork R/Neutral suitable for intravenous use in cats.


  1. US-FDA Lilly Discontinues Iletin II R & Iletin II N July 2005
  2. Iletin II R carton photo
  3. Lilly US Iletin II R Discontinuation Sheet
  4. Iletin II, etc. Regular Pork Insulin
  5. FDA-Humulin R
  6. Pork Actrapid Patient Information
  7. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Pork Actrapid
  8. Pork Actrapid Discontinuation Notice
  9. Electronic medicines Compendium (EMC) UK-Hypurin Porcine Neutral
  10. Prescribing Porcine Insulin
  11. Hypurin Porcine Neutral Patient Information
  12. Prescribing Novo Animal Insulin
  13. HealthCanada-Questions & Answers Animal Sourced Insulin
  14. the D Team-2005
  15. Intervet-Caninsulin-Product Information
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