Hypurin Bovine Lente

Use and Handling
Hypurin Bovine Lente
Lente by CP Pharma
intermediate-acting	Bovine
U100	Zinc
Line	Hypurin
Also known as	beef lente
Similar to	Iletin I Lente, Insuvet Lente
Action in cats	onset 2-3h^[1], peak 6-12h duration: maximum 18h
Action in dogs	onset 2-5h, peak 12-24h, duration: maximum 36h
Type	cloudy
Shelf Life	36 months
When opened	28 days
In pen	N/A
Notes	protect from light and heat store at 2-8C Do Not Freeze Do not use if product does not re-suspend Roll Do not use intravenously Intramuscular use not advised

Hypurin Bovine Lente is a beef-based Lente insulin made by CP Pharma^[2]^[3]^[4]^[5].

It is comparable to Insuvet's Insuvet Lente and to the discontinued Lilly Iletin I Lente.

What Lente Is Not[]

No Lente-type insulin regardless of species can contain any NPH/isophane insulin^[6] or any R/Neutral insulin^[7].

Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral^[8].

The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect^[9]^[10].

Combining Lente Family Insulins[]

Insulin manufacturers^[11] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins^[12]^[13]^[14]^[15].

None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with^[16] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action^[17].

Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins^[18].

In the UK, Best Pet Pharmacy has it in stock.

References[]

[1] Petsulin Lente Page 9 Note Re: shorter feline duration

[2] Hypurin Bovine Lente Patient Information

[3] Electronic Medicines Compendium (EMC) UK-Hypurin Bovine Lente

[4] Prescribing Bovine Insulin

[5] Hypurin Bovine Lente Lente Beef Insulin Remedyfind.com

[6] Combining Lente-type Insulins with Phenol-Preserved Insulins

[7] Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect

[8] Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination

[9] Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente Diabetes Care-1980
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GM Lente insulins

[10] Resource Guide 2005-American Diabetes Association

[11] Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins

[12] Availability of Soluble (R/Neutral) Insulin in Mixed Preparations of Crystalline (Lente) & Ultralente GE Insulins-Clinical Therapeutics-1991

[13] Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin-Diabetes Care-1987

[14] Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes Research & Clinical Practice-1983

[15] RxEd.org-Insulin Therapy-Mixing Precautions

[16] Phenol Preservatives & Lente-type Insulins--A Bad Combination

[17] RxEd.org-Insulin Therapy-Mixing Precautions

[18] RxEd.org-Insulin Therapy-Mixing Precautions

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