Hypurin Bovine Lente
Lente by CP Pharma
intermediate-acting Bovine
U100 Zinc
Line Hypurin
Also known as beef lente
Similar to  
Action in cats  
  • onset 2-3h[1],
  • peak 6-12h
  • duration: maximum 18h
Action in dogs  
  • onset 2-5h,
  • peak 12-24h,
  • duration: maximum 36h
Use and Handling
Type cloudy
Shelf Life 36 months
When opened 28 days
In pen N/A
Notes  

Hypurin Bovine Lente is a beef-based Lente insulin made by CP Pharma[2][3][4][5].

It is comparable to Insuvet's Insuvet Lente and to the discontinued Lilly Iletin I Lente.

What Lente Is Not

No Lente-type insulin regardless of species can contain any NPH/isophane insulin[6] or any R/Neutral insulin[7].

Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral[8].

The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect[9][10].

Combining Lente Family Insulins

Insulin manufacturers[11] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins[12][13][14][15].

None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with[16] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action[17].

Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins[18].

In the UK, Best Pet Pharmacy has it in stock.

References

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