Humulin R
R,Neutral by Eli Lilly
short-acting r-DNA/GE/GM
U100 none
Line Humulin
Also known as Humulin S, neutral, Toronto insulin
Similar to  
Action in cats  
  • onset 0.5h,
  • peak 2-3h
  • duration 4-5h[1]
Action in dogs  
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h
Use and Handling
Type soluble
Shelf Life 24 months
When opened 28 days room temp.
In pen 28 days room temp.
  • protect from light and heat
  • Do Not Freeze
  • May be used intravenously

Humulin R is one of several brands of "Regular" (short-acting) insulin, used for a quick consumption of blood sugar with little delay.

It consists of zinc insulin crystals dissolved in clear fluid with no additives to alter its action or speed[2].

Other brands with the same action profile include:


  1. Insulin-North American Veterinary Conference-2005
  2. FDA-Humulin R
  3. Humulin R Regular Human Insulin
  4. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin S
  5. Humulin S Prescribing Information
  6. Lilly EU/UK Product Sheet & Time Activity Profiles
  7. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Actrapid
  8. EMEA Scientific Discussion-Actrapid
  9. Prescribing Novo Insulins
  10. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Rapid
  11. Prescribing Insuman Insulins
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