Changes: Humulin N

Latest revision as of 06:57, 18 May 2018

Use and Handling
Humulin N
NPH/Isophane by Eli Lilly
intermediate-acting	r-DNA/GE/GM
U100	Isophane
Line	Humulin
Also known as	Humulin I
Similar to	Novolin N, Insulatard, Protaphane Insuman Basal, ReliOn/Novolin NPH
Action in cats	onset 1-2h, sharp peak 4-6h, duration 8-12h^[1]^[2]
Action in dogs	onset 0.5-3h, peak 2-10h^[3], duration 4-24h
Type	cloudy
Shelf Life	24 months
When opened	28 days room temp.
In pen	28 days room temp.
Notes	roll protect from light Do Not Freeze Do not use if product does not re-suspend Do not use intravenously

Humulin N is Eli Lilly's brand name for their NPH-based insulin product^[4].

It is an intermediate-acting insulin, though in cats this tends to be closer to short-acting in practise.

Like all other isophane/protamine suspended insulins^[5], it is a crystalline suspension with protamine.

NPH (Isophane) insulin was originally developed by Novo Nordisk labs in 1946, as an insulin with intermediate action. The versions currently sold are identical to human insulin and therefore differ slightly from feline and canine insulin.

Technical details

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

These times seem to be similar in dogs, but considerably compressed in cats, possibly because of cats' faster metabolism.

Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on Felinediabetes.com

Humulin N or generic NPH, and their Novo Nordisk competitor Novolin N aka Insulatard^[6]^[7]^[8]and aka Protaphane^[9], are available in the USA without a valid prescription.

In the UK, Humulin N is known as Humulin I ("I" standing for its isophane suspension.)^[10]^[11]^[12]. Aventis also makes a similar NPH insulin called Insuman Basal^[13]^[14].

References

[1] Insulins-North American Veterinary Conference-2005

[2] Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs & Cats-Nelson-OSU Endocrinology Symposium 2006-Page 41

[3] Insulins-North American Veterinary Conference-2005

[4] Humulin N NPH/Isophane Human Insulin Remedyfind.com

[5] FDA-Humulin N

[6] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insulatard

[7] Prescribing Novo Insulins

[8] EMEA Scientific Discussion-Insulatard

[9] EMEA Scientific Discussion-Protaphane

[10] Humulin I Prescribing Information

[11] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin I

[12] Lilly EU/UK Product Sheet & Time Activity Profiles

[13] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Basal

[14] Insuman Prescribing Information

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

@@ Line 1: / Line 1: @@
 {{Insulin|
-fgcolor=#fd0|
+fgcolor=#000080|
-bgcolor=#906|
+bgcolor=#d1eeee|
 name=Humulin N|
-generic=[[NPH]]|
+generic=[[NPH]]/[[Isophane]]|
 mfg=[[Eli Lilly]]|
+|- align="center" style="background:#cae1ff;border-bottom:3px solid grey;"|
 action=[[intermediate-acting]]|
 origin=[[r-DNA/GE/GM]]|
@@ Line 14: / Line 15: @@
 *[[Novolin N]],
 *[[Insulatard]],
-*[[Insuman Basal]]|
+*[[Protaphane]]
+*[[Insuman Basal]],
+*[[ReliOn/Novolin NPH]]|
 cataction=&nbsp;
 *onset 1-2h,
 *sharp peak 4-6h,
+*duration 8-12h<ref>[http://web.archive.org/web/20061101114701/http://www.cliniciansbrief.com/cms/portals/_default/pdfs/capsules/Jan_05_Cap11.pdf Insulins-North American Veterinary Conference-2005]</ref><ref>[http://images3.wikia.nocookie.net/petdiabetes/images/8/87/2006symposiumproceedings.pdf Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs & Cats-Nelson-OSU Endocrinology Symposium 2006-Page 41]</ref>|
-*duration 8-12h|
 dogaction=&nbsp;
-*onset 2-4h,
+*onset 0.5-3h,
+*peak 2-10h<ref>[http://web.archive.org/web/20061101114701/http://www.cliniciansbrief.com/cms/portals/_default/pdfs/capsules/Jan_05_Cap11.pdf Insulins-North American Veterinary Conference-2005]</ref>,
-*peak 4-10h,
-*duration 10-20h|
+*duration 4-24h|
-cloudyorsoluble=cloudy|
+cloudyorsoluble=[[cloudy]]|
-shelflife= 18 months|
+shelflife= 24 months|
 openedlife= 28 days room temp.|
 penlife= 28 days room temp.|
@@ Line 30: / Line 33: @@
 *[[Rolling insulin|roll]]
 *protect from light
+*Do Not Freeze
+*Do not use if product does not [[re-suspend]]
+*Do not use [[intravenously]]
 }}
-'''Humulin N''' is [[:Category:Eli Lilly|Eli Lilly]]'s brand name for their [[NPH]]-based [[:Category:Insulins|insulin]] product.  It is an [[:Category:intermediate-acting|intermediate-acting]] insulin, though in cats this tends to be closer to [[:Category:short-acting|short-acting]] in practise.
+'''Humulin N''' is [[:Category:Eli Lilly|Eli Lilly]]'s brand name for their [[NPH]]-based [[:Category:Insulins|insulin]] product<ref>[http://www.remedyfind.com/treatments/0/2403/Insulin:%20Humulin%20N%20etc.%20(NPH%20/%20Isophane%20Human%20Insulin) Humulin N NPH/Isophane Human Insulin Remedyfind.com]</ref>.
+It is an [[:Category:intermediate-acting|intermediate-acting]] insulin, though in cats this tends to be closer to [[:Category:short-acting|short-acting]] in practise.
-NPH (Isophane) insulin was originally developed by [[:Category:Novo Nordisk|Novo Nordisk]] labs in 1946, as a neutral insulin with intermediate action.  The versions currently sold are identical to human insulin and therefore differ slightly from feline and canine insulin.
+Like all other [[isophane]]/[[protamine]] suspended insulins<ref>[http://web.archive.org/web/20061010214819/http://www.fda.gov/cder/foi/label/2003/18781scm074_humulin_lbl.pdf FDA-Humulin N]</ref>, it is a crystalline suspension with [[protamine]].
-This type of insulin tends to have an onset of 2-4 hours, a peak action of  4-10 hours, and a total duration of 10-20 hours, in humans.  These times seem to be similar in dogs, but considerably compressed in cats, possibly because of [[cats' faster metabolism]].  Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on [http://www.felinediabetes.com/ Felinediabetes.com]
-Humulin N or generic NPH, and their [[:Category:Novo Nordisk|Novo Nordisk]] competitor [[Novolin N]] aka [[Insulatard]], are available in the USA without a prescription. In the UK, Humulin N is known as [[Humulin I]] ("I" standing for its isophane suspension.).  [[Aventis]] also makes a similar NPH insulin called [[Insuman Basal]].
+NPH (Isophane) insulin was originally developed by [[:Category:Novo Nordisk|Novo Nordisk]] labs in 1946, as an insulin with intermediate action.  The versions currently sold are identical to human insulin and therefore differ slightly from feline and canine insulin.
+==Technical details==
+This type of insulin tends to have an onset of 2-4 hours, a peak action of  4-10 hours, and a total duration of 10-20 hours, in humans.
-[[Category:Insulins]][[Category:intermediate-acting]][[Category:Eli Lilly]][[Category:Humulin]][[Category:r-DNA/GE/GM]]
+These times seem to be similar in dogs, but considerably compressed in cats, possibly because of [[cats' faster metabolism]].
+Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on [http://www.felinediabetes.com/ Felinediabetes.com]
+Humulin N or generic NPH, and their [[:Category:Novo Nordisk|Novo Nordisk]] competitor [[Novolin N]] aka [[Insulatard]]<ref>[http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=3331 Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insulatard]</ref><ref>[http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm Prescribing Novo Insulins]</ref><ref>[http://www.emea.europa.eu/humandocs/PDFs/EPAR/insulatard/206002en6.pdf EMEA Scientific Discussion-Insulatard]</ref>and aka [[Protaphane]]<ref>[http://www.emea.europa.eu/humandocs/PDFs/EPAR/protaphane/504402en6.pdf EMEA Scientific Discussion-Protaphane]</ref>, are available in the USA without a valid prescription.
+In the UK, Humulin N is known as [[Humulin I]] ("I" standing for its isophane suspension.)<ref>[http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Humulin_I.htm Humulin I Prescribing Information]</ref><ref>[http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=13398 Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin I]</ref><ref>[http://www.yorkshirediabetes.com/downloads/1071_LLY_Diabetes_RangeChar.pdf Lilly EU/UK Product Sheet & Time Activity Profiles]</ref>.  [[Aventis]] also makes a similar NPH insulin called [[Insuman Basal]]<ref>[http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=7841 Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Basal]</ref><ref>[http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Insuman_insulins.htm Insuman Prescribing Information]</ref>.
+==Further Reading==
+[[Image:Wikicat3.jpg|100px]]
+*[http://www.gorbzilla.com/nph_101.htm How to use NPH insulins on cats by Kimber & Bunny and the FDMB]
+==References==
+<references/>
+[[Category:Insulins]][[Category:intermediate-acting]][[Category:Eli Lilly]][[Category:Humulin]][[Category:r-DNA/GE/GM]][[Category:OTC Status]][[Category:Intravenous use NO]][[Category:Meta-cresol]][[Category:Phenol]][[Category:Isophane]][[Category:Phosphate]]