Diabetes in Pets
Humulin M5
R/Neutral/NPH/Isophane Mix by Eli Lilly
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Humulin
Also known as Humulin 50/50
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 24 months
When opened 28 days room temp.
In pen 28 days room temp.

Humulin M5 was the EU/UK brand name for Lilly's r-DNA/GE/GM human insulin mix consisting of 50% R/neutral insulin and 50% NPH/isophane crystal[2] insulin[3].

Lilly stopped offering this insulin in the EU & UK in July 2004[4][5].

It is the same as Mixtard 50[6][7], Actraphane 50/50[8][9] and Aventis' Insuman Comb 50[10][11].