Humulin M2
R/Neutral/NPH/Isophane Mix by Eli Lilly
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Eli Lilly
Also known as none
Similar to Mixtard 20,Penmix 20[1],Actraphane 20/80
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.

Eli Lilly's brand name for its 20% R/neutral and 80% NPH/isophane crystal[2] insulin[3] which is intermediate-acting.

It was discontinued in the EU & UK in July 2004[4][5].

Comparable insulins, both Novo-made: Mixtard 20[6][7][8][9] and Actraphane 20/80.


  1. Medsafe NZ Penmix 20
  2. EMEA Scientific Discussion Actraphane
  3. Humulin 20/80-NPH;R Human Insulin
  4. Withdrawal of Humulin M2 July 2004
  5. Lilly EU/UK Product Sheet & Time Activity Profiles
  6. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Mixtard 20
  7. Insulins & Mixtures
  8. EMEA Scientific Discussion-Mixtard
  9. Prescribing Novo Insulins
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