Humulin I
NPH/Isophane by Eli Lilly
intermediate-acting r-DNA/GE/GM
U100 Isophane
Line Humulin
Also known as Humulin N
Similar to  
Action in cats  
  • onset 1-2h,
  • sharp peak 4-6h,
  • duration 8-12h[1][2]
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h[3],
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 18 months
When opened 28 days room temp.
In pen 28 days room temp.
Notes  

This is the Euro name for Lilly's isophane-suspension insulin[4]--the "I" an abbreviation for isophane[5][6].

Lilly makes the same insulin known as Humulin N[7] in North America[8].

Like all other isophane/protamine suspended insulins, it is a crystalline suspension with protamine.

Technical details[edit | edit source]

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

These times seem to be similar in dogs, but considerably compressed in cats, possibly because of cats' faster metabolism.

Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on Felinediabetes.com.

Novo Nordisk also has their Novolin N, Protaphane and Insulatard[9][10][11][12] while Aventis has their Insuman Basal[13][14].

Further Reading[edit | edit source]

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References[edit | edit source]

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