Humulin 50/50

Use and Handling
Humulin 50/50
R/Neutral/NPH/Isophane Mix by Eli Lilly
intermediate-acting	r-DNA/GE/GM
U100	isophane
Line	Humulin
Also known as	Humulin M5
Similar to	Mixtard 50, Penmix 50^[1] Actraphane 50/50, Insuman Comb 50
Action in cats	onset Xh, peak Xh duration Xh
Action in dogs	onset 0.5-3h, peak 2-10h, duration 4-24h
Type	cloudy
Shelf Life	24 months
When opened	28 days room temp.
In pen	28 days room temp.
Notes	protect from light and heat Do Not Freeze Do not use if product does not re-suspend Roll Do not use intravenously

Humulin 50/50 is the US brand name for Lilly's r-DNA/GE/GM human insulin mix consisting of 50% R/neutral insulin and 50% NPH/isophane crystal^[2] insulin^[3].

It is the same as Mixtard 50^[4]^[5], Actraphane 50/50^[6]^[7] and Aventis' Insuman Comb 50^[8]^[9].

Lilly stopped offering this insulin, under the brand name Humulin M5^[10], in the EU & UK in July 2004^[11]^[12].

References[]

[1] Medsafe NZ Penmix 50

[2] EMEA Scientific Discussion--Mixtard

[3] Humulin 50/50-NPH;R Human Insulin Remedyfind.com

[4] Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 50

[5] Insulins & Mixtures

[6] EMEA Scientific Discussion--Actraphane

[7] Prescribing Novo Insulins

[8] Electronic Medicines Compendium (EMC) UK Patient Information Leaflet-Insuman Comb 50

[9] Prescribing Insuman Insulins

[10] Lilly EU/UK Product Sheet & Time Activity Profiles

[11] Withdrawal of Humulin M5 July 2004

[12] Lilly EU/UK Product Names & Time Activity Profiles

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