Porcine insulin (from pigs) is an exact amino acid match to that of dogs[1].
It differs from human insulin in one position. At B #30 on the B insulin chain, dogs and pigs have Alanine, while people have Threonine. It differs from bovine in two positions, both on the A insulin chain: pigs have Threonine at A #8 while cows have Alanine. At the #10 position on the A insulin chain, pigs have Isoleucine--cows have Valine.
Cats, like cows, both have Alanine in the A #8 and Valine in the A #10 positions. But cats have Histidine in the A #18 position--pork or pig insulin has Asparagine--making 3 amino acid differences between porcine insulin and feline[2].
Though this shows CP Pharma's Hypurin pork insulins[3], this information would also apply to Novo's Pork Insulatard, Pork Actrapid, and Pork Mixtard 30[4][5]. They can also be applied to compare these to Lilly's former Iletin II R and Iletin II NPH. The study at the link below found that pork R/Neutral is suitable to be used intravenously in cats[6]
These insulins are natural and entirely or partly derived from pork (pig) sources. Only Iletin I R shown on the list below was a mixture of bovine and porcine insulins; it was composed primarily of beef (apx. 85/90%).
This means that they are identical to canine natural insulin, and a bit closer to feline than human insulin is.
Many humans also prefer porcine-based insulins, which are claimed by some to give a clearer warning of impending low blood sugar than the comparable human GE and analog insulins.
Porcine Insulins[]
Porcine Insulins | |
---|---|
Hypurin Porcine Neutral Hypurin Pork Regular | |
Pork Actrapid | |
Iletin II R (No longer produced.) | |
Novo Semilente MC | |
Non-Mixed | |
Hypurin Porcine Isophane Hypurin Pork NPH | |
Pork Insulatard | |
Iletin II NPH (No longer produced.) | |
Caninsulin, Vetsulin | |
Monotard Pork (No longer produced.) | |
Iletin II Lente (No longer produced.) | |
Hypurin Porcine 30/70 Mix | |
Pork Mixtard 30 |
See also bovine insulins.
Further Reading[]
Case Studies[]
References[]
- ↑ Intervet-Caninsulin-Product Information
- ↑ BCP Veterinary Pharmacy-Bovine PZI Insulin
- ↑ Prescribing Porcine Insulins
- ↑ Prescribing Novo Animal Insulins
- ↑ Response To Withdrawal of Novo Porcine Insulins-CP/Wockhardt UK
- ↑ Pharmacology of a U40 Porcine Lente Insulin Preparation in Diabetic Cats-Journal of Feline Medicine & Surgery-Rand & Martin-2001
- ↑ Intervet-Caninsulin-Product Information
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