There's a lot to cover in the category of mixed insulins, as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane type insulin and 30% R/neutral or analog insulin.
The most common mixes are 70/30 (30/70) or 75/25 (25/75). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago.
Specifications of mixed insulins
British National Formulary classes all of them as biphasic insulins--having more than one activity or action. Regardless of their origin, the two actions are that of the fast/rapid or short acting insulin in combination with the intermediate-acting isophane or isophane-suspended analog insulin. The activity profiles of the mixed or biphasic insulins vary by whether they are analog or non-analog insulins and the fractions of the faster and slower insulins used in the mix.
There are other various mixes (all human origin) on the market in other countries; the R/neutral fraction or percentage ranges from 10 to 50. In the US, only 50/50 and 70/30 remain on the market, with a wider range available in Canada, UK and Europe.
These are not as widely varied. The "basics" are that they most commonly come in 70/30 (30/70) or 75/25 (25/75) fractions. Made of either insulin aspart (Novo) or insulin lispro (Lilly), they are a combination of the fast/rapid acting analog insulin and the same analog insulin which has been "slowed down" by a process of creating special crystals of either insulin aspart or insulin lispro with protamine suspension.
Analog mixed insulins
Humalog Mix 25
Humalog Mix 50
- Diabetes control in Siberian Husky Details about using mixed non-analog insulins with canine diabetes patient.
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