Actraphane 50/50
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Mixtard 50, Penmix 50
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.

A 50% R/neutral and 50% NPH/isophane crystal mixed insulin[1] that's intermediate-acting by Novo Nordisk.

Comparable insulins are: Humulin 50/50[2], Mixtard 50[3][4][5][6], and Insuman Comb 50[7][8]. Eli Lilly produced an identical insulin under the name Humulin M5[9] in the EU & UK; it was withdrawn in July 2004 from those markets[10].


  1. EMEA Scientific Discussion Actraphane
  2. Humulin 50/50;NPH;R Human Insulin
  3. EMEA Scientific Discussion-Mixtard
  4. Insulins & Mixtures
  5. Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 50
  6. Prescribing Novo Insulins
  7. Electronic Medicines Compendium (EMC) UK- Patient information Leaflet-Insuman Comb 50
  8. Prescribing Insuman Insulins
  9. Lilly EU/UK Product Names & Time Activity Profiles
  10. Withdrawal of Humulin M5-July 2004
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