Diabetes in Pets
Actraphane 50/50
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Mixtard 50, Penmix 50
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.

A 50% R/neutral and 50% NPH/isophane crystal mixed insulin[1] that's intermediate-acting by Novo Nordisk.

Comparable insulins are: Humulin 50/50[2], Mixtard 50[3][4][5][6], and Insuman Comb 50[7][8]. Eli Lilly produced an identical insulin under the name Humulin M5[9] in the EU & UK; it was withdrawn in July 2004 from those markets[10].